
LYOC
®

What is a LYOC ?
®
The LYOC® is a porous solution containing an active ingredient dispersed in an alveolar structure.
Very hydrophilic , it dissolves and disperses instantly in the mouth on contact with saliva.
The LYOC® can be taken directly into the mouth without additional water addition. The oral lyophilisate retains all the properties of the original liquid preparation.
BENEFITS OF LYOC® ?
Pharmaceutical Benefits
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Increased stability: the LYOC® improves chemical as well physical stability. It allows maintaining the quality of the active ingredients and preserving them in their state of optimum activity.
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Instant Solubility: the high porosity and hydrophylic properties of LYOC® allow accelerated disintegration and dissolution. The active ingredient disperses homogeneously.
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Fewer adjuvants: lyophilization decreases the amount of functional adjuvants such as preservatives, carbohydrate excipients or sodium-based compounds. It is consisting almost entirely of the active ingredient itself.
Practical and therapeutical benefits
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Action Speed: LYOC is dissolving almost instantly in the mouth so the active ingredient is rapidly available to allow mouth absorption for an earlier therapeutic action.
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Administration without water*:
Avoids exacerbations of nausea reflex encountered in many pathologies. -
User Convenience: the LYOC® can be taken at the onset of symptoms at any time and in all circumstances. LYOC® is particularly suitable for outpatient treatment**, children, elderly and patients having swallowing problems.
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Absorption through the mouth is also an advantage for liver metabolized drugs, avoiding the hepatic first-pass effect.
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The absence of sucrose and sodium in LYOC® makes a large maneuverability in diabetics, hypertensive or cardiac patients.
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With associated technologies, the LYOC® allows combining active ingredients chemically or physically incompatible , developing micronized products or coated products to mask a bad taste.


LYOC® PRODUCTION ?
Lyophilization is a freeze drying process e.g. a drying of a previously frozen aqueous or organic system.
LYOC® technology may concern all the active ingredients and all prescription or OTC drugs, but also veterinary products.
The manufacturing process of freeze dried tablets involves several steps:
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Preparation of a suspension, solution or emulsion containing the active substance(s);
Distribution of the liquid preparation in thermoformed blisters;
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Freezing at very low temperatures (-30 ° C / -40 ° C) in a short time to prevent the alteration of the active ingredient: water is totally turned into ice and active ingredient is immobilized;
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Sublimation: water as ice goes directly to vapor without passing through a liquid phase;
The finished product is a solid, porous, light and stable, having cellular structures and packaged in blister.
* With the exception of certain active ingredients, such as NSAIDs, which must be taken with a glass of water.
** The LYOC®, such as tablets and capsules cannot be taken as is by children under 6 years
due to the risk of swallowing it the wrong way; it must be dissolved in a small amount of drink.