LYOC

®

BENEFITS OF LYOC® ?​

Pharmaceutical Benefits 

• Increased stability: the LYOC® improves chemical as well physical stability. It allows maintaining the quality of the active ingredients and preserving them in their state of optimum activity. 

• Instant Solubility: the high porosity and hydrophylic properties of LYOC® allow accelerated disintegration and dissolution. The active ingredient disperses homogeneously. 

• Fewer adjuvants: lyophilization decreases the amount of functional adjuvants such as preservatives, carbohydrate excipients or sodium-based compounds. It is consisting almost entirely of the active ingredient itself. 

​Practical and therapeutical benefits 

• Action Speed: LYOC is dissolving almost instantly in the mouth so the active ingredient is rapidly available to allow mouth absorption for an earlier therapeutic action. 

• Administration without water*:
  Avoids exacerbations of nausea reflex encountered in many pathologies. 

• User Convenience: the LYOC® can be taken at the onset of symptoms at any time and in all circumstances. LYOC® is particularly suitable for outpatient treatment**, children, elderly and patients having swallowing problems. 

• Absorption through the mouth is also an advantage for liver metabolized drugs, avoiding the hepatic first-pass effect. 

• The absence of sucrose and sodium in LYOC® makes a large maneuverability in diabetics, hypertensive or cardiac patients. 

• With associated technologies, the LYOC® allows combining active ingredients chemically or physically incompatible , developing micronized products or coated products to mask a bad taste. 

LYOC® PRODUCTION ?​

Lyophilization is a freeze drying process e.g. a drying of a previously frozen aqueous or organic system. 

LYOC® technology may concern all the active ingredients and all prescription or OTC drugs, but also veterinary products. 

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The manufacturing process of freeze dried tablets involves several steps: 

• Preparation of a suspension, solution or emulsion containing the active substance(s); 

  Distribution of the liquid preparation in thermoformed blisters; 

• Freezing at very low temperatures (-30 ° C / -40 ° C) in a short time to prevent the alteration of the active ingredient: water is totally turned into ice and active ingredient is immobilized; 

• Sublimation: water as ice goes directly to vapor without passing through a liquid phase; 

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The finished product is a solid, porous, light and stable, having cellular structures and packaged in blister. 

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* With the exception of certain active ingredients, such as NSAIDs, which must be taken with a glass of water. 

** The LYOC®, such as tablets and capsules cannot be taken as is by children under 6 years 

due to the risk of swallowing it the wrong way; it must be dissolved in a small amount of drink.